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Prolonged use of Vitamin B6 (over 2 months) at high doses exceeding 1g/day can lead to severe peripheral neuropathy, with symptoms including unsteady gait and numbness in the hands and feet

This assessment may help support a more personalized conversation with your provider about which supportive therapies align with your genetic profile, though genetics alone do not predict exact treatment response

Some patients begin with a short series of NAD+ treatments to support energy and focus, then transition to maintenance sessions spaced weeks or months apart

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Conversely, controlled enhancement of fatty-acid oxidation [e.g., via peroxisome proliferator-activated receptor alpha (PPAR) signaling] can sometimes rescue T cell energetic capacity in low-glucose settings, highlighting a context-dependent, bidirectional role of lipid metabolism [139]