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Many widely used chemotherapy drugs, including platinum-based agents (oxaliplatin, cisplatin, carboplatin), taxanes (paclitaxel, docetaxel), vinca alkaloids (vincristine, vinblastine), proteasome inhibitors, and thalidomide analogues may cause direct neurotoxicity and CIPN (Zajczkowska et al., 2019)

Although they are not able to catalyze glutathione S -conjugation reactions at significant rates, they are considered to belong to the glutathione S -transferase (GST) superfamily (Dixon and Edwards, Glutathione peroxidase (GPX) Although GSSG could be generated as a product of GSH-dependent DHA reduction, genomics has revealed the complexity of the plant antioxidative system and identified several GSH-dependent enzymes that may play more direct roles in peroxide metabolism

Future research should elucidate this more thoroughly

[124] [135] Moreover, clomipramine may be able to achieve more complete occupancy of the SERT at high doses, at least relative to fluvoxamine

Discussion Metabolic derangement accompanying influenza infection has been increasingly recognized as having an important role in the pathogenesis of virus-induced lung injury