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Environmental disturbances are the leading causeprolonged irregular light exposure, such as that caused by social jetlag and shift work, can directly impair the synchronization of the biological clock (Takahashi et al., 2018

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This further validated the model, provided a spectrum of new insights into how the NGV metabolic system may age, and allowed us to identify potential strategic interventions that could repair the aging metabolic system, which could take the form of dietary and lifestyle changes or even drug targets

[DOI] [PubMed] [Google Scholar] 111.Milone M., Di Minno M.N.D., Lupoli R., Maietta P., Bianco P., Pisapia A., Gaudioso D., Taffuri C., Milone F., Musella M