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However, most ferroptosis-related drugs for breast cancer are still in the preclinical stage ( Formononetin, an isoflavone compound derived from a variety of medicinal plants and herbs such as including Trifolium pratense and Astragalus membranaceus , has been identified as exhibiting anticancer potential against various cancer types, such as cervical, head and neck, colon, breast and ovarian cancers ( via the inhibition of Akt activity (Zhou et al., 2019), indicating its potential as a therapeutic agent for breast cancer inhibition

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