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4 In dopaminergic PC12 cells, decrease in cellular GSH leads to reduction of E1 activity which subsequently disrupts the ubiquitin pathway

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Consistent with the binding affinities acquired by SPR, GLP-1 LX exhibited the weakest binding and dissociated from the column first at pH 6.3, followed by GLP-1 WT at pH 6.7 and Tanzeum at pH 6.9 (Fig