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[DOI] [PubMed] [Google Scholar] 57.Moschos M., Droutsas D

AOD 9604 does not increase IGF-1 levels

Inflammatory responses and metabolic disorders in the tumor microenvironment suppress immune cell activity.The product inhibits NNMT, reduces inflammatory factor levels, improves the tumor microenvironment, promotes immune cell infiltration and activation, and thereby enhances the recognition and killing of tumor cells by immunotherapeutic agents, offering a new strategy for cancer immune combination therapy

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NNMT methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor