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Z.AshfaqM.JavedM

Therefore, the result of the desirable properties obtained with the incorporation of cereblon ligands in the construction of PROTACs, together with the excellent therapeutic results published in recent years, obtained by forced induction of the degradation of a specific POI by cereblon-based PROTACs in vitro, ex vivo and in vivo, and for different types of diseases, make this type of PROTACs the leaders in the field of TPD

doi: 10.1007/s00213-017-4561-5 239 MorenoFAParkinsonDPalmerCCastroWLMisiaszekJEl KhouryAet al

Additionally, an increased presence of intraepithelial lymphocytes further reinforces their immunogenic nature, indicating a potential for responsiveness to immunotherapy (46)

Notably, serum MDA levels were elevated at all melanoma stages, with the highest levels being observed in stage IV patients, thus suggesting a direct correlation between tumor stage and LPO levels [111]
