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ROS production was measured using the method of Hayashi et al

MOTS-c (/products/mots-c) is a mitochondrial-derived peptide acting through AMPK and metabolic signalling

However, several recent studies demonstrate that hyperactivation of the Nrf2 signaling cascade favors the survival of both normal and malignant cells, protecting them against oxidative stress, and chemotherapeutic agents [40, 41]

The two forms coexist, but an imbalance in the tetramer: monomer ratio can lead to the preponderance of pro-aggregating forms

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