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Subsequently, non-enzymatic self-oxidation occurs with molecular oxygen under the catalysis of the Fenton reaction, which is initiated by iron and H 2 O 2 to produce phospholipid peroxyl radicals (PLOO), which are generated by removing hydrogen from another PUFA to generate PLOOH ( Figure 1A )

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Systemic Therapy (Severe / Refractory) Methotrexate (weekly oral/injection), cyclosporine for rapid clearance, acitretin for pustular/erythrodermic types

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