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It is also found in the diet, mainly in red meat and certain animal-based products

It does this by transporting fat into the mitochondria of cells

It has been shown that heme iron lead to increased endogenous formation of NOC including N-nitrosothiols, and nitrosylated heme in the gastrointestinal tract during digestion of red meat [59]

Iran J Kidney Dis 13:7486 Bruls YM, de Ligt M, Lindeboom L, Phielix E, Havekes B, Schaart G, Kornips E, Wildberger JE, Hesselink MK, Muoio D, Schrauwen P, Schrauwen-Hinderling VB (2019) Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: a randomised controlled trial

Correlation analyses further reveal a close association between alterations in gut microbiota composition and changes in serum metabolites, suggesting that hawthorn flavonoids exert anti-obesity effects by modulating the gutmetabolic axis (71, 72)