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Description
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In the context of AD, a marked reduction in BDNF levels in the cortex and hippocampus has been reported [123,124,125]

Genome Res (2002) 12(6):9961006

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Nasal deliverys proximity to the olfactory nerve pathway provides a potential direct CNS access route that has generated specific research interest in intranasal neuropeptide delivery studies making the nasal spray format a distinct and research relevant presentation compared to injectable DSIP preparations for protocols examining central neuropeptide activity
