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We thank Stefano Manzoni for typing the manuscript and for the art work, and Mrs Jean Ringrose for the scientific and English editing of the manuscript

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The generation of oxidative DNA lesions, such as 8-oxoguanine (8-oxoG), is linked to the development of various cancers, including melanoma, while the accumulation of these lesions can compromise genomic stability, leading to mutations and the eventual transformation of normal cells into malignant ones 53

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