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There is ample evidence that compounds attached to a propargylamino group induce molecular processes which act against cell death mechanisms like apoptosis, excitotoxicity and oxidative stress

Administration of these nanoparticles significantly decreased iron content and oxidative stress levels in the substantia nigra and striatum of PD mice and effectively reduced their dopaminergic neuron damage and as reversed their neurobehavioral deficits, without causing any overt adverse effects in the brain or other organs

Finally, it has strong socioeconomic impact, by reducing physical obstacles and enabling remote participation (for disabled, elderly, remote locations etc.), while it reduces costs related to the voting process i.e

Treatment protocols often involve daily injections for 10-20 days, repeated as needed

This broad neuromodulatory profile may explain both DSIPs therapeutic potential and the difficulty researchers have had identifying a single receptor-level mechanism of action