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[76] [14] [9] The Thr92Ala DIO2 polymorphism is present in 1236% of the population

During the aftermath of the acute COVID-19 pandemic, we are faced with a newly identified infection-associated chronic condition (IACC): Long COVID [336]

This process depends on: Vitamin B6 (P5P) as an essential enzyme cofactor Adequate availability of glycine and glutamate Sufficient cellular energy (ATP) Proper liver and mitochondrial function When this pathway is inefficient, glutathione production may be impaired even if homocysteine, B12, or folate levels appear normal

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No such mutation has been identified in humans