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The mechanical strain and shear stress, resulting from altered hemodynamics, lead to endothelial cell and epithelial cell injury, which accelerates the occurrence and development of proteinuria (Bai et al., 2022)

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Besides epithelial cells, EGFR activity was the highest in neutrophils expressing high levels of S100a9 , as well as in the Spp1 + macrophage/monocyte cluster of AOM/DSS tumors (Fig

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