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Description
Macrophage-inducible C-type lectin (Mincle) can activate KCs through recognizing a damaged hepatocyte releasing endogenous ligand, named spliceosome-associated protein 130 (SAP130), to exacerbate APAP hepatotoxicity

Other mutations such as p.R336C alter the molecular properties of CBS, leading to a severe HCU phenotype unresponsive to B6 therapy (42)
[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Masubuchi Y., Nakayama J., Sadakata Y

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