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DOI: 10.3382/ps.2010-0075 21

Notably, studies have reported that DSIP-mediated analgesia occurs without the tolerance development typically seen with exogenous opioid compounds, suggesting a fundamentally different mechanism of interaction with the opioid system

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Post-transcriptional regulation of GCLM has been described with HNE, which increased the stability of GCLM mRNA by a mechanism that required de novo protein synthesis (Liu et al., 1998)
