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One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation

Theyre usually prescribed for more severe cases of muscle spasms

Incorporate regular stretching exercises: Regular stretching can help improve muscle flexibility, thereby reducing the likelihood of spasms

Vitamin B12 injections are generally very safe

Methylcobalamin helps rebuild that covering