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Studies show that CrAT overexpression in primary human skeletal myocytes increases glucose uptake and attenuates lipid-induced suppression of glucose oxidation, demonstrating the importance of carnitine-dependent metabolic pathways in preserving insulin sensitivity and metabolic health

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After assessing all identified studies for each disorder, a GOR ranging from A (solid evidence) to D (limited, inconsistent, or inconclusive evidence) was assigned (see Table 3) to each disorder

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Insights into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Phenotypes through Comprehensive Metabolomics