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Concurrently, Dox-induced ROS accumulation and damaged organelles activate the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, resulting in cleavage of pro-caspase-1, activation of caspase-1, and subsequent maturation and secretion of the pro-inflammatory cytokines interleukin-1 (IL-1) and interleukin-18 (IL-18)

10.1016/j.carbpol.2023.121163 188 WuF.ChenL.DuY

Given that the transcription factor ATF3 induces P21 CIP expression while high c-Jun activity represses P53-mediated P21 CIP induction, 38, 39 the precise c-Jun/ATF2 and ERK1/2 activations regulate the transient increase in p21 CIP protein amounts required to stabilize CyclinD/CDK4/6 complexes from 36 to 40 h in WT mice

SIRT1 has been implicated in both tumorigenic and anticancer processes, and is reported to regulate essential metabolic pathways, suggesting that its activation might be beneficial against disorders of the metabolism