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The production of ROS and inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), transforming growth factor 1 beta (TGF-1), and interleukin-6 (IL-6) results in inflammation which causes tissue damage and directly induces DNA damage (Damm et al

We searched ClinicalKey, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, MEDLINE, PubMed and ScienceDirect for relevant studies published from 1 January 2000 to 30 April 2020
