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Description
The amyloid cascade hypothesis which is based on the molecular defects observed in autosomal-dominant EOAD has been severely criticized due to the unsolved paradox: Why do A aggregate into fibrils?, but it is clear that the A sequence, A concentration, and conditions that destabilize A are important factors in aggregation [83, 84]
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Pyruvate can, in turn, be transformed to Lactate, restoring NAD + needed for anaerobic glycolysis and production of ATP (Figure 1B)
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