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The role of gut-dependent molecule trimethylamine N-oxide as a novel target for the treatment of chronic kidney disease

Results: Preclinical studies consistently show that ALA attenuates liver injury by improving liver enzymes, oxidative stress markers, inflammatory cytokines, and histopathological changes, typically at doses of 50200 mg/kg in rodents

Inflammatory stimuli cause the release of cytokines such as interleukin (IL-1), IL-6, and tumor necrosis factor-a (tnf-a), which increase the synthesis and release of CRP [156]
Singh PB, Matanhelia SS, Martin FL
