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1 illustrates the essential reactions and feedback mechanisms among ROS, GSH, GSSG, NADPH and G6P in the outer retina, which we focus on and model as a system of ordinary differential equations (ODEs), where all parameters are non-negative

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The method according to any one of claims 7 to 11, characterized in that the calcium salt of N 5 , N 1o- methylene-5,6,7,8-tetrahydrofolic acid is prepared by reaction at room temperature of 5,6,7,8- Tetrahydrofolic acid in water with a compound selected from the group consisting of alkali metal hydroxides, alkali metal carbonates, alkali metal bicarbonates, ammonia and organic bases containing nitrogen, such as pyridine, triethylamine, triethanolamine, then a water-soluble, aromatic, nitrogen-containing base to this salt solution thus prepared adds which is selected in particular from the group consisting of pyridine and substituted pyridines, for example picolines, lutidines, ethylpyridines, pyridine being preferred, then reacting the salt solution thus prepared with formaldehyde, and then adding an aqueous solution of a calcium salt, where the calcium salt of N 5 , N 1 -methylene-5,6,7,8-tetrahydrofolic acid re fails

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Normalized CE was set at 25%