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Among deubiquitinating enzymes, ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) was found to be oxidatively modified in AD brain, and its activity was also found to be reduced (18, 305, 342, 357)

Studies have shown that L-carnitine supplementation can improve cognitive function, memory, and attention span
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ALS can occur at any age, but its peak incidence is between 50 and 75 years and sharply decreases after 80 years (Vinceti et al., 2019)
