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Description
Intrinsic factor deficiency causes pernicious anemia, which may be associated with subacute combined degeneration of the spinal cord

[PubMed: 2161554] 242

As such, secretory trafficking not only plays a role in synaptic function, but it also underlies neuronal differentiation and spine morphogenesis, with previous studies demonstrating that the manipulation of proteins involved in regulated secretory trafficking [11, 28, 29] or manipulations that block secretory trafficking [30] result in decreased dendritic outgrowth and impaired neuronal differentiation and spine morphogenesis

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A rac -GR24-dependent ShD14ShMAX2 interaction was also observed, which strongly suggested that ShD14 might serve as an SL receptor
