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By inhibiting the folate cycle and de novo purine synthesis, MOTS-c triggers an AMPK-driven shift that encourages the body to burn fuel rather than store it

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5-amino-1-methylquinolinium) combined with low-fat diet (LD) promoted dramatic whole-body adiposity and weight loss in diet-induced obese (DIO) mice, rapidly normalizing these measures to age-matched lean animals, while LD switch alone was unable to restore these measures to age-matched controls in the same time frame

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