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Description
However, a recent report in which a high-fat diet induced insulin resistance, obesity and addictive-like behaviours up to the third generation did not identify heritable changes in the DNA methylome 123

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Ozdem S, Aliciguzel Y, Ozdem SS, Karayalcin U

J Med.Toxicol

In addition, this structure does not provide an explanation for the negative cooperativity in the binding of IGF1 to IGF1R, a classic feature of both IR and IGF1R for which the mechanisms are poorly understood 9,10
