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When HYP mutation was introduced to Y37 of rat amylin(2737), the affinity for amylin receptor 1 ECD was further increased by 5-fold compared to the affinity increase by Y37P mutation (Figure 6A and Table 2)
(1997) Vitamin B12 treatment for delayed sleep phase syndrome: a multi-center double-blind study
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Conclusion: To our knowledge, this is the first case study to report on reducing biological age, increasing telomere length, and improving cognition using this unique combination of therapies in a patient with mild to moderate cognitive decline
