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Furthermore, LS has been proven to have antioxidant properties in a rat model of diabetic nephropathy produced by streptozotocin, as demonstrated by a decrease in renal MDA levels and an increase in renal SOD, catalase, and GSH levels 60

Persistent inflammatory responses driven by DNA damage, ER stress, and autophagy disruption contribute to cellular senescence, tissue fibrosis, and possible transgenerational effects [12]

The excess ROS, including superoxide anion (O 2 ), singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH), and so on, would induce oxidative damage to biomolecules (e.g., proteins, lipids, and DNA) and, thus, lead to severe cellular damage ( 2 (Rothenberg et al., 2003), CP of 350 mg/m 2 (Krarup-Hansen et al., 2007)] and can be characterized by sensory neurotoxicity (e.g., sensation loss and changes) due to the accumulation of Pt drugs at the peripheral nervous system ( To solve the challenge, numerous researchers devote to exploring the mechanism of PIPN, which are principally implicated in transporter overexpression (Sprowl et al., 2013), ROS upregulation (Leo et al., 2020), ion channel dysfunction (Janes et al., 2015), and so on

Spectrochim Acta A Mol Biomol Spectrosc 327:125408 Han LJ, Wu SP, Yang JH, Mao GJ, Chen TF, Wang QQ, Zhang GF (2024) A glutathione-activatable near-infrared fluorescent probe with a large Stokes shift for imaging 4T1 tumor and its ferroptosis