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it is not recommended that patients engage in fat-freezing treatments at home

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Glucocorticoids, for example, regulate the expression of glucocorticoid-sensitive genes by binding to glucocorticoid (GR) or mineralocorticoid receptors (MR) and subsequent activation of transcription through glucocorticoid/mineralocorticoid response elements ( GREs / MREs ) in gene regulatory regions 21,22

Combining two ingredients that both have GI side effect potential could theoretically worsen tolerability, particularly during the early dose titration phase when the body is still adjusting to tirzepatide