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Reversible weakness and encephalopathy while on long-term valproate treatment due to carnitine deficiency

It transports long-chain fatty acids, which are oxidized and broken down to produce energy, into the mitochondria

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It is possible to establish a plausible mechanistic explanation using 1) the performance outcomes of the present investigation in combination with 2) previously established mechanisms of the underlying carnitine molecules, and 3) recent reports of increased muscle carnitine levels via insulin infusion

Another small study conducted in 2010 by Sapienza Universitys Department of Clinical Medicine found that combining L-carnitine with caloric restriction can reduce insulin resistance and improve sensitivity