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While identification of the different molecular signatures and genotypes among responders and non-responders may help develop predictive biomarkers to enable patient stratification in clinical setting, the molecular and genetic heterogeneity in many tumors is still a big challenge for successful cancer therapy [182]

12 Specifically, NAC is thought to affect thioredoxin expression, which regulates DNA binding of NF-kB and glutaredoxin expression that is responsible for detecting changes in the redox state of GSH

Consistent with decreased fasting glucose levels and improved insulin tolerance observed under chow, and to a lesser extent under HFD conditions (Figure 1, H and I, and Figure 2, J and L), GSH depletion significantly downregulated gluconeogenic enzymes G6pc and Pck1 in chow-fed mice, with no substantial change under HFD (Figure 3, A and B)

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