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the clinical relevance of this finding in humans is unknown, and in UK and EU prescribing information this is noted as a precaution rather than a formal contraindication but individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their doctor

Some researchers have conceptually explored combining both strategies for potentially synergistic effects on intracellular NAD+ levels, though no published data exists for this specific combination

Spiekerkoetter U, Vockley J

[DOI] [PubMed] [Google Scholar] 7.Cumming DE, Overduin J

Patients should also be aware that folate supplementation should not be started before B12 deficiency has been treated, as doing so can precipitate or worsen neurological complications