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The Institute of Medicine has not established a tolerable upper intake level of B12 because studies show no adverse health effects when taking excess levels of B12, either through food or supplements

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For example, GRACILE syndrome ( G rowth R etardation, A mino aciduria, C holestasis, I ron overload, L actic acidosis, and E arly death) is caused by mutations in the BCS1L gene which is required for proper assembly of complex III
Nanomedicine (Lond)

doi: 10.1515/znc-2024-0116 3 ShangSYangHQuLFanDDengJ
