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showed that LptA was inhibited by thanatin, a peptide of 21-residues containing a disulfide bond (GSKKPVPIIYCNRRTGKCQRM) (Figure S11) that is naturally derived from an insect, Podisus maculiventris

On the other hand, exosomes from cells with reparative potential, such as bone marrow mesenchymal stem cells (MSCs) or amniotic epithelial cells, have been found to downregulate the pro-ferroptotic lipid metabolism enzyme ACSL4, or upregulate parallel anti-ferroptosis pathways like FSP1/GPX4, thereby attenuating ferroptosis and promoting cartilage repair (Wang Y

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If weight loss is the primary goal, tirzepatide is the evidence-based intervention
