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Strength points and limitations Based on our knowledge, this is the most updated meta-analysis on this topic, including all available evidence based on our inclusion criteria of including only controlled studies, either RCTs or controlled observational studies, to reach the highest accessible quality of evidence from the available evidence found in the literature

1000 g daily) may be able to produce adequate absorption of vitamin B 12 even in the presence of intrinsic factor deficiency, and therefore may be an alternative to the intramuscular route for many people

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