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The burden remains highly concentrated, with three-quarters of cases located in the Western Pacific (97 million), Africa (65 million) and South-East Asia (61 million) [2]

2.2 Clinical relevance of DTP cells in AML 2.2.1 Chemotherapy and targeted therapy resistance DTP cells are closely related to the treatment response of AML and are one of the key factors leading to resistance to chemotherapy and targeted therapy

Exposure to IFN-, a Th1 cytokine, resulted in increased GSH levels, whereas exposure to IL-4, a Th2 cytokine, resulted in decreased intracellular GSH

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