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The NO pathway plays an important role in intestinal smooth muscle function and mucosal protection, and disruption of this system is associated with certain inflammatory bowel presentations

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Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )