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[Google Scholar] 48.Cox AR, McDowell S

Many patients seek treatment after noticing signs of aging, such as fine lines, wrinkles, uneven skin tone, loss of skin firmness, or diminished skin elasticity

This is a secondary-prevention result in people who already had heart disease

Cardiovascular or respiratory disease, renal or hepatic impairment, diabetes, Helicobacter pylori infection, rheumatoid arthritis, and hypertension are also associated with increased risk
