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Sequence or disulfide bridge pattern of key peptides were confirmed using MALDI-TOF MS-MS analysis or proteomic analysis (enzymatic digestion followed by MS characterization of the fragments)

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Notably, the observed harm appears independent of dosagetypically 2030 mg/daysuggesting a threshold-independent mechanism

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The environment can also alter DNA methylation or histone modifications, regulating the expression of inflammatory genes and enhancing the innate immune response ( Figure 2 )

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doi: 10.1093/brain/awv350 35 HoriK.KatayamaM.SatoN.IshiiK.WagaS.YodoiJ

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