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Detection of cytosolic DNA by cGAS enables its dimerisation and subsequent generation of the second messenger cGAMP by using ATP and GTP

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The GHR belongs to the class 1 cytokine receptors which uses STAT as one of its principal secondary messengers, and the subsequent phosphorylation of two STAT5b molecules results in a phospo-STAT5b homodimer which translocate to the cell nucleus, binds to STAT5b recognition sites on the IGF1 gene promoter, and initiates transcription (Figure 3)

E coul is the Coulomb energy value, which is calculated using the charge of the system with the permittivity of 1