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The docking results revealed that the compounds were bound well in the active site of the targets

In the present study, we determine (1) whether co-injections of L-NAC or L-NACme diminish the development of acute physical dependence elicited by injections of fentanyl in male Sprague Dawley rats, as assessed by the withdrawal responses elicited by injection of the -OR antagonist, naloxone HCl (NLX), and (2) whether co-injections of L-NAC or L-NACme to rats that are physically-dependent on fentanyl could overcome this dependence, again assessed by the expression of the NLX-precipitated withdrawal responses

Availability of data and materials The data underlying this article cannot be shared publicly due to proprietary restrictions

she declares she received stock options from Calibrate, Epitomee, Scientific Intake and Xeno Bioscience

Undoubtedly, the primary benefit of enhancing the GABA content in crops and food matrices lies in its significant potential to positively impact human health, and consumers are already acquiring tomatoes with genetically enhanced GABA (Ahmar et al., 2023a, Ahmar et al, 2023b)