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Notably, this Treg induction is independent of Toll-like receptor (TLR)/Nucleotide-binding Oligomerization Domain (NOD)/Card9 pattern recognition receptor signaling pathways

Reduced availability of T3 and the possibility of hypothyroid-like symptoms despite normal T4 levels are caused by insufficient Se, which impairs the operation of DIO1 and DIO2 [35]

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Overall, with its low toxicity, multitarget effects, and potential to mitigate complications, Scrophularia radix represents a promising natural candidate in antidiabetic drug development