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Natural compounds such as piperlongumine and cotylenin A exhibit synergistic therapeutic efficacy with SAS, which suggest that the triple combined treatment with piperlongumine, piperlongumine and SAS is highly effective against pancreatic cancer (Kasukabe et al., 2016
doi: 10.1002/(SICI)1096-8628(19960628)63:4 3.0.CO;2-L
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Retrieved October 2, 2015
Subsequently, prostaglandin and thromboxane generated by cyclooxygenase as well as leukotrienes generated by lipoxygenase from arachidonate (20:4n-6) function as lipid mediators
