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Research shows that when PARP1 depletes cellular NAD+, it disrupts the NAD+/SIRT1 system, which leads to faulty DNA repair and reduced cell survival
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At 3 months, the total glutathione (tGSH), GSH and GSSG levels in the whole homogenate did not significantly differ between mutants and controls
doi: 10.3390/ijms23073797 60 Otulak-KozieK.KozieE.TrederK.KirlyL
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