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doi: 10.1111/resp.12229 125 KaluzaJHarrisHWallinALindenAWolkA

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A classical biomarker of CHO restriction is the amount of circulating KBs

Possible mechanisms include the inhibition of the activity of phase-I-enzymes (CYPs), regulation the expression of nuclear factor erythroid 2related factor 2 (Nrf2) and Nrf2 target genes, suppression of tumor cells growth, inhibition of angiogenesis by the regulation of VEGF (vascular endothelial growth factor) and metastasis and reduction of the proliferative capacity of cancer cells by altering their metabolism [24]

10.3390/ijms19020590 178 SkrottZ.MistrikM.AndersenK