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93,94,95,96 As the key inflammatory mediators of disc degeneration, TNF- and IL-1 can induce disc degeneration by decreasing anabolic ECM proteins, such as aggrecan and collagen II, and promoting catabolic enzymes, such as a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4 and -5 and matrix metalloproteinases (MMPs)-1, -2, -3, -4, -13, and -14

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Previous studies on the effects of BPC-157 peptide have shown positive and rapid healing effects of various muscle injuries, characterized by fewer accompanying hematomas and swelling or absence of post-injury contractures

Acknowledgements Editorial support was provided by Richard Ogilvy-Stewart of Apollo, OPEN Health Communications, and funded by Novo Nordisk A/S, in accordance with Good Publication Practice guidelines (www.ismpp.org/gpp-2022)