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Over time, mutated mtDNA molecules can undergo clonal expansion, and once the mutational burden exceeds a critical thresholdtypically 60% and 90% they produce a biochemical defect in OXPHOS, a concept referred to as the mtDNA mutational load (112)

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Effects include reduced inflammatory markers in synovial fluid, preserved cartilage thickness on imaging, improved joint function scoring

Toch blijft het volledige werkingsmechanisme onbekend

Observed Changes Post-treatment, patients often report a gradual lightening of skin tone, along with improved skin texture and a more even complexion