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The selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs) elevate levels of 5-HT and NE in the extracellular space and activate intracellular signaling pathways, which universally lead to CREB phosphorylation and BDNF transcription from its gene [282]

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Int J Mol Sci 24(1):12

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